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Controlling Microbial Growth - Coggle Diagram
Controlling Microbial Growth
terms
Sterilization-kill all microbes on nonliving
disinfection-kill 99.9 microbes on nonliving
Antisepsis- kill vegetative pathogs on living
Degerming-kill microbes on limited skin area
sanitization-lower micro lvl to public safe
microbial control
alter-membrane permeability
damage to proteins
damage to nucleic acids and their replication
antimicrobial drugs
efficacy depends on-how long exposed, #microbs, environment
Bacteriocidal-dirrectly kills 99.9%
bacteriostatic-prevents reproduction keeps in static lag state
physical methods
autoclave- bacteriocidal-wet dry heat
dry heat-bacteriocidal-bactcinerator, flame, medical wast incinerator
pasturization-bacteriocidal-milk72c for 15s doesn't sterilize
filtration-0.2u(microns) or HEPA 0.3u
low temps-bacteriostatic-listeriosis can live at refrige temp bad for pregnant-causes premature birth miscarage stillbirth
osmotic pressure-salt or sugar and 'smoking'
Radiation-gama rays-destroys DNA UV rays-damage DNA
antimicrobial
Ehrlich-magic bullet chemotherapy
selective toxicity- kill microb without damage to host
difficult with fungus bc Eukariotic
Broad spectrum-kills normal flora too leads to competitive inhibition could cause super infection but saves time no ID
narrow spectrum-specific doesn't kill normal mostlikely works takes more time bc ID infection
Therapeutic index= toxic dose/therapeutic dose