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Glomerulonephritis - Coggle Diagram

- - - - Urine microscopy (red-cell casts)
      - Urine dipstick
      - urine PCR
    - - FBCs
      - U&Es
      - LFTs
      - bone profile
      - CRP
      - ESR
      - nephritis screen (ANA, ANCA, anti-GBM, C3/C4)
    - - USS KUB
    - - Kidney biopsy
- - - - Characterised by allergic asthma, rhinitis and eosinophilia
      - Approx 30% have renal involvement, 50% of these present as RPGN
      - Majority of patients are pANCA positive (anti-MPO)
      - Kidney biopsy shows a focal and segmental necrotising GN with eosinophilic infiltration
      - AKA Churg strauss
    - - Characterised by pulmonary haemorrhage (30%), RPGN and signs of systemic vasculitis
      - Kidney biopsy shows a focal and segmental necrotising GN which is pauci-immune
      - Majority of patients pANCA positive (anti-MPO)
    - - GPA is characterised by upper respiratory-tract symptoms, pulmonary haemorrhage (70%), RPGN and signs of systemic vasculitis
      - Kidney biopsy shows a focal and segmental necrotising GN which is pauci-immune
      - majority are cANCA positive (anti-PR3)
      - AKA wegners granulomatosis