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GI drugs- other drugs - Coggle Diagram
GI drugs- other drugs
Motility modifying drugs to increase motility
rabbits with decreased GI motility
cats with megacolon
Cisapride (upper + lower GI)
enhances release of Ach from postganglionic nerve endings at myenteric plexus
complex effects at serotonin receptors
restricted availability in humans due to side effect of serious cardiac arrhythmias
off label use
Ranitidine (upper GI + some effect on lower GI)
Metoclopramide (some effect on upper GI)
Motility modifying drugs for D+
Opioids
increase segmental contractions in gut--> random + multi-directional
prolong intestinal transit time
allow greater time for fluid to be absorbed
relieve abdominal pain and tenesmus
reduce frequency of defecation
rarely required
acute D+ usually self-limiting
chronic D+ usually doesn't respond to symptomatic therapy
Anticholinergics
decrease peristalsis
little use
mostly patients have hypomotile rather than hypermotile gut so reduction in peristalsis is not desirable--> delayed gastric emptying + ileus
may be justified in short term
Mirtazapine
oral/transdermal
need to know WHY animal is inappetent
cats with kidney + liver dz but dose adjustment needed--> every 48hrs
Probiotics
little confirmed clinical efficacy
Role of antibiotics in GI disease
NEVER use in cases of vomiting due to dietary indiscretion/gut toxicity
only use for acute D+ if specific infectious cause suspected, not just because there is blood in faeces
antibiotic responsive chronic enteropathy is a specific syndrome that does not = infectious D+
histiocytic colitis in boxers + related breeds
Fibre!!