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Inhibitory NON-GABA Agonist - Coggle Diagram
Inhibitory
NON-GABA Agonist
Ketamine
MOA
Binds to multiple CNS receptors
NMDA Antagonist
Produced CNS depression
Opioid Agonist
S isomer to Mu receptor
Dissociative state
EYES OPEN , NO ONE HOME
Dissociation between thalamocortical and limbic system
Intense analgesia and amnesia
Pharmacokinetics
Metabolized by CYP450
Norketamine
Redistributes out of the central compartment
Highly lipid soluble
Poorly protein bound
Pharmacodynamics
CNS
Decreases seizure risk
Dissociative State
Hallucination
Decreased with co-administration with benzodiazepines
Less common in children
INCREASED CBF and CMRO2
Cardiovascular
Increased HR and BP
Increased sympathetic response
Respiratory
MINIMAL EFFECTS
Airway Reflex
Increased salivation
Bronchodilation
Dosing
Induction
IV: 1-2 mg/kg
IM: 4-8 mg/kg
Sedation
PRN IV Bolus: 0.2-0.8 mg/kg
Clinical Indication
Prevent Opioid-Induced Hyperalgesia
Multimodal:
3-5 mcg/kg/min
Dexmedetomidine
Scopolamine
Droperidol