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Inhibitory GABA Agonist - Coggle Diagram

- - - - Propofol
      - Soybean oil
      - Glycerol
      - Egg phosphatide
  - - - Increased Cl- channel opening
      - Hyperpolarize the postsynatic
    - - Increased affinity of glycine
      - Inhibit NMDA receptor
      - Block nicotinic receptors in brain
      - Inhibits lysophosphatidate signaling
  - - - Rapid awakening
  - - - Decreased CMRO2
      - Burst suppression
      - Neuroprotection
    - - Vasodilation
      - Attenuated baroreflex (mild increase HR)
    - - GREATEST Apnea
      - Decreased RR and Tidal Volume
      - Decreased Upper Airway Reflex
    - - ANTIEMETIC
      - Propofol INFUSION SYNDROME
  - - - Adult: 1.5-2.5 mg/kg
        Children: 2-3 mg/kg
        Elder: Reduce by 25-50%
    - - 100-300 mcg/kg/min
- - - - Hyperpolarize the postsynaptic
      - Increased Cl- channel opening
  - - - Decreased CBF and CMRO2
      - Activates seizures
      - Produces MYOCLONIC movement
    - - LEAST EFFECTED : HR and BP
    - - Decreased RR
    - - Adrenocortical Suppression
      - Pain
      - INCREASED postoperative nausea and vomiting
  - - - 0.2 - 0.4 mg/kg
- - - - Increased Cl- channel opening
      - Increased Cl- conductance
      - Hyperpolarize the postsynaptic
      - Resistance to excitation
  - - - Oral Adult: Diazepam 5-15 mg
      - Oral Children: Midazolam 0.25 - 1 mg/kg
      - Nasal: Midazolam 0.2 mg/kg
    - - Midazolam 0.05-0.15 mg/kg
    - - Midazolam 1 mcg/kg/min
      - PRN Bolus: Midazolam 0.05 mg/kg
    - - PRN Bolus: Midazolam 0.5-1 mg
      - PRN Bolus: Diazepam 2 mg
      - PRN Bolus: Lorazepam 0.25 mg