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PUD - Coggle Diagram

- - - - disrupted mucus–bicarbonate layer and tight junctions
      - decreased prostaglandins
        
        increased neutrophils
        
        edema
        
        vascular congestion
        
        epigastric tenderness
        
        decreased appetite
        
        weight loss
        
        nausea
      - increased gastrin
        
        increased acid output
        
        acidic pH activates pepsin
        
        protein digests exposed tissue
        
        damaged mucosa
        
        ulceration and bleeding
        
        1 more item...