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Hypersensitivity, TREATMENT Immunotherapy (allergy shots), Mediated by T…
Hypersensitivity
Type IV
Delayed Type Hypersensitivity (DTH)
Th2
Eosinophil activation
Chronic asthma
allergic rhinitis
CTL
cytotoxcity
contact dermatitis
Nickel and posion Ivy
Th1
Macrophage activation
DTH (Delayed Type 4 Hypersensitivity) Rxn
Contact (Posion Ivy)
Tuberculin (PPD)
Granuloma
AUTOIMMUNITY
Type I Diabetes
Rheumatoid Arthritis
Multiple Sclerosis
Type III
(soluble immune complexes)
IgG
Arthus Rxn (can be transient)
Uritcarial rash from
SERUM SICKNESS
Hemorrhage in skin
AUTOIMMUNITY
Systemic Lupus Erythematosus
Type II (formation of covalent bonds
with cell surface proteins)
IgG
Hemolytic anemia
Blood Transfusion Rxs
Hemolytic Transfusion rxn
antibodies bind to transfused RBC
Acute Hemolytic Transfusion Reaction (Fever, chills shock)
Delayed Hemolytic Transfusion Reaction (milder symptoms)
Febrile non-hemolytic transfusion rxn
(Host antibodies against donor HLA antigens/ Leukocytes)--MILD
HDNB (hemolytic disease of new borns)
AUTOIMMUNITY
Graves
Mystania Gravis
Goodpasture
&
Autoimmune hemolytic disease
(thrombocytopenia)
Type I
IgE (soluble antigen)
Mast cell activation
Immediate Rxn
MAST CELL DUMP
Wheal and Flare Rxn
Late-Phase Rxn
New MAST CELL PRODUCTS
Widespread edema
Blood Transfusion Rxn
Anaphylactic Rxn
(see above) More severe
IgA deficient can't receive whole blood
w/. IgA
Allergic Rxn
(against plasma proteins in
transfused blood)
TREATMENT Immunotherapy
(allergy shots)
Increase TH1 (IFNY)
Decrease TH2 (IL-4)
Increase Treg (CD25 & Foxp3)
Mediated
by T-Cells
Fixed Surface
Tryptase
Histmaine
Heprain
TNG-alpha
Lekuotrines
Platlet activating factor
IL-4, IL-13
IL-3, IL5, GM-CSF
Treatment: Anti-IgE Antibody
Treatment: cromolyn (inhibits mast cells)
Treatment: Leukotrines antagonist
Treatment: antihistamine
Treatment for Anaphylaxsis: Epineprhine