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Nucleus - Coggle Diagram
Nucleus
nuclear lamina
structural support
DNA replication
gene regulation
made up of lamin proteins
can be anchored to the nuclear lamina
aids disassembly/ reassembly
role of phosphorylation
addition of phosphate group
via covalent linkage to nuclear lamina
nuclear pores
acts as nuclear gate
free diffusion
ions/ small macromolecules (~9-10nm,< 40-60 kDa)
pass freely and
non selectively
through NPC
active transport
larger molecules (>9nm)
energy is required to transport into and out of nucleus
nucleolus
RNA synthesis
assembly of ribosomal subunits
nuclear active transport
NIR binds to
NLS
and target protein to NPC
Receptor- cargo complex binds to NPC
Receptor- cargo complex cross NPC
receptor separates from the protein releasing into nucleus
NIR returns to cytoplasm through NPC (
hydrolysis
of GTP
)
(transported protein contains targeting signal in its
primary amino acid sequence
)
nuclear envelope
double membrane
outer
continuous with rough ER
ribosomes attached