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COVID-19 - Coggle Diagram
COVID-19
Epidemiology
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RF
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- Exposure to virus - viron load
- Non-hospitalised < hospitalised < ICU
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TUH Mx
- Medical / Psychological Assessment
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- Personalised plan for a staged return to normality
Goal
Rule out alternative underlying diagnosis
- Metabolic issues
- Sleep apnoea
- Interstitial lung disease
- asthma
- Airway disease
- Thyroid problems
- Anaemias
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Complications
Methylation analyses found accelerated biological aging, sometimes up to 10 times
- Lung Changes and Fibrosis
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- Effects on the Brain / Cognitive Impairement
Pathogenesis
- Virus may enter brain via nose and olfactory bulb
- Circultated to affect frontal parietal lobes
- Hypometabolism in these regions
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- Biological aging of brain
- Disregulation of brain activity in fronto-parietal areas
- Functional correclation: Frontoparietal areas contain the Multiple demand netowrks - supports executive function (attention, reasoning, judgement, problem solving)
Deregulation aligns with reported symptoms - lack of concentration / brain fog
Prognosis
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Prediction
Will improve with time - most symptoms including metabolic dysfunctions observed in muscle biopsies do improbe
Definition
Signs and symptoms that develop during or following an infection consistent with COVID-19 that continue for (1) >12 weeks and (2) are not explained by an alterantive diagnosis