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Cytokines, Activate Endothelial Cells Inc vascular permeability, Activate…
Cytokines
Interlukins (numbered in order)
IL-7 (--> Lympocytes): B & T cells
IL-5--> Eosinophils
IgA promotion
IL-3 --> RBC and Platelets
IL-1 (local inflamation-->act.
phagocytes)
IL-8 OR CXCL8
IL-6 (Act. lymphocytes)
IL-12 (EARLY INNATE) ACT NK and CTL's
Produced by macrophage and Dendritic cells
Releases IFN-Y
IL-10
(INHIBITOR)
IL-2 (Released from CD4-->CD8)
T-cell proliferation
IL-4-->help in B cell activiation
B cell switching to IgE
IL-13
B cell switching to IgE
IL-17 -->ACUTE Inflammation
IL-21 (B cell act./ Tfh differentiation)
IL-22 Maintenance of epithelial barrier
Interferons (IFNs): INTERFERE
Type II
IFN Y
IgG2a promotion
Type I
IFN alpha-->
Immune Cells
IFN B (Fibroblast)
Tumor Necrosis Factors (TNFs)
TNF B
TNF a (activitaes
inflammation)--> act. phagocytes
Transforming Growth Factors
TGF-B
(INHIBITOR)
: T-cells
IgA promotion
Colony Stimulating Factors
(Hematopoiesis)
Activate Endothelial Cells
Inc vascular permeability
Activate Macrophages and CD4 Helpter T cells
CHEMOKINE
CD4 & Th1
Innate:
TNF-a
IL-1
IL-8
IL-6
IL-12
IFN a & B
IL-10
Hematopoisesis
IL-7
IL-5
IL-3
Adaptive
IL-2
IFN-y
TGF-B
INHIBTORS:
IL-10
TGF-B
In innate only
Decrease Protein Synthesis