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Cancer Genetics - Coggle Diagram
Cancer Genetics
Mutation
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Hasil mutasi yang menyebabkan kanker dapat diinduced oleh radiasi, karsinogen, bad lifestye
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substitusi,insersi,delesi,inversi, aneuploidi dll
Gene amplification
- can coexists
- increasing copy number gworth gene
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Cause of Mutations
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Tautomeric shift=>perubahan bentuk umum dri keto menjadi enol, jumlah basa yg jarang dapat memicu mutasi
Oxidative Stress (ROS)=> byproduct oxygen metabolism if accumulate can damage cell molecules (oxidative DNA damage)
Induced mutation
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Karsinogen (Ciggs, food, coal dust)
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Oncogene
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Proto-oncogen (pre-existing normal genes), tidak ditularkan karena mutasi somatik, induced by retrovirus
proto-oncogenes turned into oncogenes in the absence of virus with the help of H-ras protooncogene in human bladder. Transformation of NIH 3T3. MEKANISMENYA GIMANA?
Myc oncogene mechanism:
- Provirus integration
- Gene amplification
- Chromosomal translocation
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