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Immune memory - Coggle Diagram
Immune memory
Innate
Epigenetic modification
Histone acetylation
Increased chromatin accesibility and modified gene expression
H3K9ac and H3K27ac
Histone methylation
Heterochromatin formation and limited transcription
H3K4me and H3K36
Metabolic reprogramming
Pro-inflammatory
.- OXPHOS
.+ Glycolysis
.+ Biosynthesis
Anti-inflammatory
+OXPHOS
+- Glycolysis
+- Biosynthesis
Adaptive
Dendritic cells present antigen on cell membrane, migrate to lymph nodes
T-cells that recognise antigen bind to antigen -> Th cell
Immature B-cells pick up antigen and start presenting it on cell surface
Th cell binds to antigen on B-cell and release stimulatory cytokines
Rapid proliferation
Differenentiation into plasma cells and memory B-cells
Memory B-cells remain in body