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Pluripotent Hematopoetic stem cells, GM-CSF is ook een cytokine dat een…

- - - - Transcription factors that play a role in differentiation: BATF3, ID2, IRF8, PU.1, NFIL3
        
        Cytokines that induce differentiation: SCF
    - - Transcription factors that play a role in differentiation: IRF4, ID2, ZEB2, Notch2, RORyT, T-bet
      - Cytokines that induce differentiation: SCF
    - - Transcription factors that play a role in differentiation: IRF4, IRF8, E2-2, ZEB2 Cytokines that induce differentiation: FLT3L
  - - - Erythrocyte
    - - Platelets
- - - - ILC2
        
        Differentiation is induced by the cytokines: IL25, TSLP, IL-33, TLR4 (pathogens) Transcription factors: , RORa, GATA3,GFI1
      - ILC3
        
        Differentiation is induced by the cytokines1; IL-23, IL-6, IL-1, Transcription factors: RORyT, AHR, ID2
      - ILC1
        
        Differentiation is induced by the cytokines: IL-12, IL-15,IL-18 Transcription factors: T-bet, TCF1, RUNX3
      - LTi
        
        Differentiation is induced by the cytokines: closely related to ILC3, so probably very similar Transcription factors: RORyT, AHR, ID2
      - Common NK precursor> NK cell
        
        Differentiation is induced by the cytokines: balance of activatory and inhibitory receptors, IL-15
        Transcription factors: T-bet, EOMES, Hobit
    - - Common CD4 T-cell precursor
        
        Naive T-cell
        
        Th17
        
        Differentiation is induced by the cytokines IL-6, TGF-beta, IL-23, IL-21
        Transcription factor:RORyT, STAT3
        
        TFH
        
        Differentiation is induced by the cytokines: IL-6, IL-21, TGFb Transcription factor: Bcl-6, STAT3
        
        Th2
        
        Differentiation is induced by the cytokines: IL-4, IL-5, IL-10, IL13, TGFb
        Transcription factor: GATA-3, STAT6
        
        Treg
        
        Differentiation is induced by the cytokines: TGFb, IL-2 Transcription factor FoxP3,
        
        Th1
        
        Differentiation is induced by the cytokines: IFN-gamma and IL-12
        Transcription factors:T-bet, STAT4, STAT1
        
        Th9
        
        Differentiation is induced by the cytokines: TGF-beta, IL-2, IL-4 Transcription factor: IRF4, PU.1, SMAT 2,3, GATA3
      - CD8