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Innate lymphoid cells > IBD - Coggle Diagram
Innate lymphoid cells > IBD
How do they normally function in a network
Intestinal homeostasis
ILC1
Lamina propria ILC1
Intraepithelial ILC1
IFN-y production to combat infections
ILC2
They occur in the fetal gut, but are less common in the adult intestine < lower numbers than ILC1/3.
Goblet cell differentiation, Tissue repair
IL-13 production
Areg production > maintaining epithelial homeostasis
induce activation of eosinophils, mast cells and macrophages
ILC3
Maintain gastro-intestinal tract homeostasis
IL-22 production
activates intestinal epithelial cells to produce antimicrobial peptides
enhances the renewal of epithelial cells
enhances the renewal of epithelial cells
enhances the renewal of epithelial cells
IL-2 production
Tolerance through T-regulatory cells
LTi
peyers patches and lymphoid follicles
interaction with B-cells facilitates IgA production
promotes host commensalism with local bacteria
Disturbing of the network
IBD
Alterations to ILC population disturb gut homeostasis and lead to gut inflammation
ILC1 population is expanded
in response to IL-12/IL-15
produce IFN-y
more inflammation in gut
ILC3
lower IL-22 expression
IL-22 binds to the IL-22R to trigger the production and maintenance of IL-18 mRNA and promote IL-18 signaling in epithelial cells.
Reduction in barrier integrity
higher expression of IL-17
induced by IL-6
ILC2
il- 33 is increased, which leads to enhanced colitis
numbers are higher in inflamed regions
plasticity etc
Contribution to auto-immune diseases
see powerpoint slide
