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Upstream scenario with Dari and Steffy Yusei's iteration, Test strips…
Upstream scenario with Dari and Steffy Yusei's iteration
Test strips designed to change color in the presence of cholinergic plant neurotoxins
Pros:
Quick and easy, accessible
cultural appropriateness
Supports Independency
Cons:
Limited Accuracy
Limited supply
How can this be made?
Prepare a Inert filter paper
Attach enzymes or binding proteins that interact specifically with plant toxins (eg: acetylcholinesterase or mimetic peptides) onto Colloidal gold nanoparticles (AuNPs).
In the presence of cholinergic neurotoxins, protective coating on AuNPs is damaged, it initiates a color change of the test paper.
This allows for a low-cost and visual detection of the presence of neurotoxins.
Part 1. Introducing the scene
What's happening?
villagers are fishing, farming, working by the river
When and where?
Upstream, river adjacent to lush vegetations
Villagers regularly attemps to clear the vegetations due to safety concerns
Water Hemlock
Cholinergic Toxicity
Socrates
Releases toxins when damaged (especially the root)
The clearing of vegetation linked to increase in cases of villagers collapsing
Part 2. How is this affecting the human body?
Acetylcholine build up causing overstimulation of the nervous system
Part 3. Engineering approach
Neurotoxins test strip
Cholinergic Toxicity
Symptoms
Nicotinic Symptoms
Muscle twitching
Muscle weakness
High blood pressure
Seizures
Parasympathetic system
Tearing (lacrimation)
Diarrhea
Vomiting
Pinpoint pupils (miosis)
secretions (difficulty breathing)
Excessive salivation
Skeletal muscles
Motor neurons
Collapse, tremors, loss of coordination
Root of Hemlock
