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COPD Chronic obstructive pulmonary disease, Environment สูบบุหรี่ …
COPD
Chronic obstructive pulmonary disease
Environment
สูบบุหรี่
มลพิษ
Inflammation
Inflammatory mediators
หลั่งez protease มากขึ้น
Destruction of alveolar wall and capillaries
Enlarged air spaces
Emphysema
Hypoxemia
Hypoxic vasoconstriction small pulmonary arteries
Pulmonary hypertension
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impaired gas diffusion
Air trapping on expiration
fibrosis and thickening of the bronchiolar walls
narrowing of small airway
Choronic bronchitis
goblet cell ทำงานมากขึ้น
mucus hypersecretion
Genetic
α- antitrypsin deficiency
loss antiprotease