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Scleroderma - Coggle Diagram
Scleroderma
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• Degenerative changes in skin, blood vessels and viscera -Y abnormal fibroblast
activation increased production of extracellular matrix (type 1 collagen),
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Cutaneous
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- starts progressiveiy from distal to proximally.
- affects upper extremities more than lower.
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- rewarming -5 hyperemia and redness.
- may induce digital tip ulcers (scarring) and gangrene (falling).
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Raynauds 
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