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Androgen Drugs, Adrenocorticosteroids - Coggle Diagram
Androgen Drugs
Androgen suppression/ anti-adrogens
Long-acting GnRH analogs
mechanism: desensitize receptor: by causing G-protien receptor degradation
Leuprolide acetate
Goserelin
GnRH antagonists
don't exist yet!!!
Inhibitors of androgen synthesis
Ketoconazole
How: Blocks P450s active in steroid synthesis; increases estrogen:testosterone ration
Side Effects: gynecomastia in males
DHT Inhibitors
5-alpha-reductase inhib
Type I enzyme
Dutasteride
oral med, longer half life/ slower onset
Type II enzyme
Finasteride
treats benign prostate hyperplasia
Androgen receptor antagonists
-amide suffix
Flutamide
treats advances prostate cancer
other ___amides
usually coupled w/ GnRH agonist
mechanism: inhibits DHT binding to androgen receptor!
Cyproterone Acetate
CYP17A1
abiraterone
GnRH antagonist
Degarelix & Relugolix
Testosterone/ Androgenic Analogs
All end in "-one" with a few exceptions
Methyltestosterone
oral/sublingual
Fluoxymesterone
Oral
Oxymetholone
Use for anemia
Testosterone
transdermal/ topical
Danazol
treats endometriosis via negative feedback on the pituitary excess production inhibits earlier step in the pathway.
Dan the man is muscular!!
Side effects of use
sideffects of testosterone
elevated liver injury
Male pattern baldness
Treatments!
Decreased libido
Adrenocorticosteroids
Corticosteroids
Treating athritis
Intermediate acting
fludrocortisone
Fluid
cortisone for fluid retention (through aldosterone like signaling?? confirm this)
triamcinolone
long acting
Dexamethasone
Dexter is long and smart
short acting
Cortisone
Cortisol
