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Ch 16 - Coggle Diagram
Ch 16
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Antiparallel Elongation
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DNA polymerases add nucleotides only to the free 3′ end of a growing strand; therefore, a new DNA strand can elongate only in the 5′ → 3′ direction
Along one template strand of DNA, the DNA polymerase synthesizes a leading strand continuously, moving toward the replication fork
To elongate the other new strand, called the lagging strand, DNA polymerase must work in the direction away from the replication fork
The lagging strand is synthesized as a series of segments called Okazaki fragments, which are joined together by DNA ligase
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DNA Replication:
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Replication in bacteria is best understood, but evidence suggests that the replication process in eukaryotes and prokaryotes is fundamentally similar
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Replication
Origins of replication
Replication begins at particular sites called origins of replication, where the two DNA strands are separated, opening up a replication “bubble”
At the end of each replication bubble is a replication fork, a Y-shaped region where parental DNA strands are being unwound
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