You play as Akil, a former Medjay (elite warrior/policeman) whose village is destroyed by unnatural storms and plagues. Soon, it becomes clear that Set, god of chaos and disorder, is manipulating the balance between the mortal world and the afterlife, trying to overthrow Ma’at (the principle of cosmic order).
The gods are either willing to assist, corrupted, or murdered by other mortals with their essences controlled by them. To stop Set, you must acquire the "Aspects" of the gods — powers or spiritual fragments representing what they stood for — and use them to combat his growing influence.