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Group of primordial follicles stimulated, Sperm arrive in vagina, LH surge…

- - - - Paracrine factors, as well as others (like GH)
- - - - Continue growing
        
        Increase estrogen and Inhibin B production
        
        Suppresses
        
        FSH starts rising
        
        Stimulates transition to
        
        Rescues some follicles
        
        Decreased FSH starves less developed follicles
        
        Atresia
        
        Most developed follicle is most sensitive to FSH
        
        Survives the low FSH environment
        
        Becomes the dominant follicle
        
        1 more item...
- - - - Capacitation
        
        Fast Events
        
        Bicarbonate transported into sperm
        
        AC activated
        
        cAMP produced
        
        PKA activated
        
        1 more item...
        
        Slow Events
        
        Increases sperm membrane fluidity and permeability
        
        Preparation for upcoming acrosome reaction
        
        Acrosome is a large secretory vesicle in sperm head, containing digestive enzymes
      - Ca++ influx amplifies pathway
      - Albumin draws cholesterol out from membrane
- - - - End of Zygote state
        
        First cell division occurs (cleavage) ~24hrs after fertilisation
        
        Continues dividing
        
        Embryo reaches 8-cell stage
        
        Compaction
        
        Increased cell adhesion molecule expression (E-cadherin) and formation of tight junctions
        
        2 more items...
        
        First Cell Fate Decision
        
        2 more items...
        
        All cells are totipotent
        
        Every cell has ability to form either any embryonic cell type and any extraembryonic tissue (like placenta)