Please enable JavaScript.
Coggle requires JavaScript to display documents.
Receptors, Extra, Cholinergic receptor responds to acetylcholine - Coggle…
Receptors
-
4TM receptor
4 Transmembrane regions
5 Subunits (alpha, alpha2, beta1, delta, epsilon/Gamma
Non-polar center
Polar outer
Channel
TM2 is more polar since it is the located in the center.
TM1, TM3, TM4 are non-polar since its located in the membrane.
Mechanism
Neurotransmitter -> Induced fit -> Domino effect -> rotation of TM2 regions of each protein subunits
-
Signal Transduction
GCPR's
Mechanism:
Messenger bind -> Induced fit -> G-protein released -> GTP can bind -> Activate Signalling
-
-
Kinase Receptors
Mechanism:
Messenger binds extracellularly ->
Intracellular active site opens ->
intracellular reaction (phosphorylation) ->
Messenger Falls off -> Active site closes
Extra
Agonists
-
Partial Agonist (Binds the on and off forms, with slight preference for on)
-
-
-
-
-
-
-
-