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drug therapy in males and females - Coggle Diagram
drug therapy in males and females
abstract
methodology
"This review explores the influence of sex as a biological variable in drug delivery, pharmacokinetic response and overall efficacy in the context of pharmaceutical research and practice in the clinic."
purpose
talk about the adverse effects of approved drug products in women
discussion
question posed
‘Why can’t a woman be more like a man?’
bias towards men
women experiencing adverse drug reactionsmore often than men
sex-gap exists in pharmaceutical research
supporting evidence
Prescribe more drugs
require more health care service
more hospitalizations due to ARD (age-related differences)
more predominant to chronic disease
Alzheimer's
influenza
pneumonia
factors that effect intended medication use
distribution
sex differences affect how drugs respond at their target sites in the body
metabolism
can be dependent on the sex of the individual due to transporters and enzymes expressed in hepatocytes
can be effected by height, weight and body surface area
absorption
the body doesn’t take in the full dose of medication taken
Menstrual cycles
female menstrual cycle splits hormone cycles into three phases
follicular
ovular
luteal
important information
link
https://www.sciencedirect.com/science/article/pii/S0169409X21001782?casa_token=ikxgJJSwxlQAAAAA:IZwIq4AI4E8IxYWgts18cvRS3AglujZ7RtjGZoUOSLj4UaropXEtPSFR_4Va5vC0vA7MU5mBd0I
authors
Christine M. Madla, Francesca K.H. Gavins, Hamid, A. Merchant, Mine Orlu a, Sudaxshina Murdan, Abdul W. Basit
title
Let’s talk about sex: Differences in drug therapy in males and females
citation (CSE)
Madla CM et al. Let’s talk about sex: Differences in drug therapy in males and females. Advanced drug delivery reviews. 2021;175(113804):113804.
http://dx.doi.org/10.1016/j.addr.2021.05.014
.
https://doi.org/10.1016/j.addr.2021.05.014