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Puncture wound right hand, 5 days ago - Coggle Diagram
Puncture wound right hand, 5 days ago
C.Tetani spores enters and germinates
Anaerobic environment (deep, no oxygen, no debridement)
Tetanospasmin production and spread
Tetanospasmin enters motor neurons at NMJ
Retrograde transport to CNS inhibitory interneurons
Cleaves synaptobrevin
blocks GABA & glycine release
Disinhibited motor neurons
Excess ACh release
4 more items...
Fever 37.8°C (Neuroinflammatory Response)