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Adrenergic & Anti-Adrenergic Drugs - Coggle Diagram
Adrenergic & Anti-Adrenergic Drugs
𧬠Autonomic Nervous System (ANS)
π§ CNS vs. PNS
βοΈ Somatic (Voluntary) vs. Autonomic (Involuntary)
πΉ Sympathetic
πΈ Parasympathetic
π§ͺ Neurotransmitters
πΉ Adrenergic (NE, E)
πΈ Cholinergic (ACh)
πΊ Dopaminergic
π Serotonergic
π§ GABAergic
π Cholinergic System
π SSRRT Process
π§ͺ Synthesis (Choline + Acetyl-CoA)
π¦ Storage (Vesicles)
π Release (via Ca2+)
π― Response (M/N Receptors)
β Termination (AChE breakdown)
π Cholinergic Drugs
β Agonists (e.g. Pilocarpine)
β Antagonists (e.g. Atropine, Botulinum)
𧬠Cholinesterase Inhibitors (e.g. Neostigmine)
β€οΈ Adrenergic System
π SSRRT Process
πΉ Tyrosine β DOPA β Dopamine β NE β E
π¦ Vesicular Storage (VMAT)
π Release (Ca2+ dependent)
π― Adrenoceptors (Ξ±, Ξ²)
β Termination
π Reuptake (NET)
𧬠Degradation (MAO, COMT)
𧨠Interfering Drugs
π« Metyrosine (Synthesis Blocker)
𧱠Reserpine, Bretylium (Storage/Release Blockers)
π Cocaine, TCAs (Reuptake Inhibitors)
π Amphetamine (Reversed Transport)
π― Adrenergic Receptors
πΈ Alpha
β¬οΈ Ξ±1 β Vasoconstriction, mydriasis, prostate/bladder tone
β¬οΈ Ξ±2 β βNE release, βinsulin, platelet agg.
πΉ Beta
β€οΈ Ξ²1 β βHR, βcontractility, renin release
π¬οΈ Ξ²2 β Bronchodilation, vasodilation, uterine relaxation
π₯ Ξ²3 β Lipolysis
πΊ Dopamine
π― D1βD5 (mainly in CNS, kidney)
π Adrenergic Agonists
β‘ Direct
π― Selective
Ξ±1: Phenylephrine, Midodrine
Ξ±2: Clonidine, Dexmedetomidine
Ξ²1: Dobutamine
Ξ²2: Terbutaline, Ritodrine
π― Non-selective
Epinephrine, Norepinephrine, Isoproterenol
π£ Indirect
𧨠Releasing Agents: Tyramine, Amphetamine
π« Reuptake Inhibitors: Cocaine, Atomoxetine
π MAO/COMT Inhibitors: Selegiline, Entacapone
π Mixed
πΈ Ephedrine
πΈ Pseudoephedrine
π‘οΈ Adrenergic Antagonists
β Alpha Blockers
π§ͺ Non-selective: Phenoxybenzamine, Phentolamine
π― Ξ±1-selective: Prazosin, Tamsulosin
π― Ξ±2-selective: Yohimbine
β Beta Blockers
π Ξ²1-selective: Metoprolol, Atenolol
π£ Non-selective: Propranolol, Timolol
βοΈ Mixed Ξ±+Ξ²: Labetalol, Carvedilol
π Clinical Applications
β€οΈ Cardiovascular
π©Ί Hypertension, Angina, CHF
π¬οΈ Pulmonary
π« Asthma, COPD (Ξ²2 agonists)
ποΈ Ophthalmology
ποΈ Glaucoma (Ξ±1 agonists, Ξ² blockers)
π½ Urology
π¦ BPH (Ξ±1 antagonists)
π§ CNS
𧩠Parkinsonβs (Levodopa)
β‘ ADHD, Narcolepsy (Amphetamine, Modafinil)
π Anaphylaxis
𧬠EpiPen (IM Epinephrine)
π‘οΈ Steroids + H1/H2 blockers