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Biological theories of ageing (Lecture 3) - Coggle Diagram
Biological theories of ageing (Lecture 3)
Wear and tear
every species has a biological clock which determines max life span and rate of decline
body wears out over time, a though a pre programmed process
cellular ageing
cells undergo a finite no. of replications
ageing happens when cells slow their no. of replication
telomeres at ends of chromosomes shorten w each cell division. once shortened to a critical length, cell stops replicating and dies
Immunological theory
declining ability of T-cells(related to immune system) in ageing organisms to replicate
unable to fight infections
ageing occurs as body's immune system does not work well w time
Cross linkage
concentrates on age related changes in a protein called collagen
changes linked to stiffening of joints and wrinkles
The binding of glucose to protein, which requires oxygen, causes the protein to become defective and unable to work optimally
Mitochondrial DNA mutation
theory
Mitochondria provide the energy needed by the body
Mutated forms of mitochondrial DNA (mtDNA) accumulate in the body with ageing. Unclear if is a cause or by-product of age- related deterioration and death
Ageing is caused by reactive oxygen species that attack the mitochondria and cause harm to the cell
Ageing may be caused by faults in the repair or replication of damaged DNA in the mitochondria