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BM (LCH mf, dend, BRAF gene, CD1a, Langerin irregular "…

- - - - Congenital > Fanconi anaemia {AR} (normocytic, marrow hypoplasia)
      - Acq > infec, radiation, chemtherapy, AI
    - - Thalassaemia
      - Sickle cell
    - - Congenital
      - Acquired (as part of the MDS)
    - - Sideropenic : Fe def / micro-hypo
      - Sideroblastic: ring-shaped w/ mitochondria full of Fe
      - Anemia of Ch diseases: infec, AI, tumors
  - - - Enz
        
        Glu-6-FDH defect (XR)
        
        Pyruvate kinase defect
      - HB pathy
        
        Thalassaemia
        
        Sickle cell
      - Mem (conge)
        
        Hereditary spherocytosis (AD)
        
        Paroxasmal nocturnal hemoglobinuria : mut in PIG anchor
    - - Allo-imm
        
        Post-transfusion reaction
        
        Hemolytic disease of the newborn (HDN) : Rh & maternal IgG
      - Non-imm
        
        Microangiopathic: due to TTP, HUS, DIC, :<3:valve
        
        infection, toxin, burn
      - Auto-imm
        
        Cold haemoglobinuria (4 deg - IgM)
        
        Warm (37deg - IgG)