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Hemostasis Disorders - Coggle Diagram

- - - - Clinical Issues
        
        PTT increased
        
        menorrhagia, epistaxis (nose bleed)
      - What VWF does normally: vWF is produced by the Weibel-Palade bodies of endothelial cells and acts as a ligand for platelet adhesion; it also plays a role in fibrin clot formation by acting as a carrier for factor VIII.
- - - - mucocutaneous bleeding
      - thrombocytopenia
      - elevated bleeding time
      - lack of aggregation
    - - autosomal recessive mutation in the GpIb receptor on platelets that prevents receptor binding with von Willebrand factor
    - - Uncle Benard Gacpah London
  - - - antiplatelet antibodies
        
        Glanzmann Thrombasthenia
        
        cause/ mechanism
        
        GpIIb/IIIa
        
        clinical symtpoms
      - no Low RCB Count
    - - cause/ mechanism
        
        development of autoantibodies against the enzyme ADAMTS13; ADAMTS13 cleaves von Willebrand factor
      - clinical symptoms
        
        fever, anemia, thrombocytopenia, elevated creatinine, and altered mental status
        
        Low RBC count!
        
        due to hemolytic attack of RBCs by large vWF multimers (not cleaved)