Please enable JavaScript.
Coggle requires JavaScript to display documents.
Epidemiology - Trials - Coggle Diagram
Epidemiology - Trials
Randomisation
-
Groups likely to have similar characteristic by chance - distributes both known and unknown confounders qually between control and experiment groups
Reduces selection bias if pts enter trial before randomisation - recruit, consent, randomise
-
-
-
Blinding
Single blind - patient, clinician or assessor does not know allocation
Double blind - two or more of pt, clinician, assessor does not know tx allocation
-
-
-
Ethical Issues
- Reasonable uncertainty about which treatment ins better - Clinical Equipoise
-
-
Study Designs
-
Experimental
Nonrandomatised
-
Disadvantages:
Selection bias
Reporting bias
Confounding - groups may diff systematically other than in tx given
RCT
Trial : Experiment or intervention (not passi9ve observation)
Controlled: Resemble labratory experiemnt in basic science
Randomised: Random allocation of exposure
-
-
-
Stopping Rule
Harm
Procedures in place for immediate unblinding of clinician in the event of serious s/e or other emergency
-
Cost
Terminate to safe resouces if preliminary data indicate clear benefit on the primary endpoint due to the intevention
-