Please enable JavaScript.
Coggle requires JavaScript to display documents.
Liver & Lung repair devices (anything about MEMS left in notes, near…
Liver & Lung repair devices (anything about MEMS left in notes, near end)
-
Tissue engineered liver
liver soft tissue, mainly type I & II collagen
encapsulate the cells and inject, manufacture around cells, do not damage them
-
-
-
-
-
Open cell: gaps between cells, most biomed materials
Electrospinning
-
1) as solution leaves needle, it's drawn to collector by electrical field and whirls about getting longer and narrower
-
-
-
-
-
dual core electrospinning uses double needles to produce hollow fibres or inner and outer layers with different materials
-
Oxygenator (Lungs)
-
-
-
-
-
-
-
-
-
same principles of flow as kidney dialysis, just wwith oxygen instead of dialysate (look at notes there)
membrane oxygenator
diffusion mechanism (silicone), O and CO2 diffuse across membrane
microporous (polyurethane), direct contact between gas and blood
shapes: hollow fibre, flat plate,coil
materials: polymethylpentene, polypropylene, polysiloxane, poly(vinyl chloride), polycarbonate
-
typically bundles of polymethlypentene hollow fibres, 1-2micrometers thick, 380micrometers outerdiameter woven with polyethylene terephthalate (PET) filaments surface area 1.8m^2
-
-
-
Microchannel Lungs
-
-
channels are thin, hence high surface area to blood ratio
Lab on a chip
-
can separate individual physiological functions in the human body into components and can model them in precise detail
can replace animal testing of: biocompatibility, haemocompatibility, drug cocktail combination
-
control and manipulation of small volumes, reactions and biological experiments
-
shorter diffusion distances, fast heating, high SA:V
-
-
-
single molecular sensitivity of DNA, RNA and protein biomarkers
-
-
-
Cell Lines
-
-
can be animal, human or both
-
-
HeLa cells
-
cells from her cancer reproduced very well, doubling every 20-24hrs
-
-
also used to test AIDs vaccine, human papilloma virus, etc
-
-
-
Organ on a chip
-
-
-
-
-
-
-
Tumour models
primary cancers rarely kill someone, its the secondary tumour
organ on chip used to model what happens in patient during potential treatment options and how cancer will spread
-
culturing cells with only 1 variety of tissue does not replicate in vivo position, need a model with 2 or more tissues
