medical history, -Age gender demographia
Palor, bruising, recurrent infection
Weakness,
examination and performance status
leukemia cutis, Chloroma
Gingival hypertrophy
Hepatospenomegaly
Lymphadenopathy, CNS symptoms
Full blood count and differential – low Hb, plt, wbc,
Retics- decrease
PBS – NN anemia, Blast
Bone marrow aspirate- hypercellular, blast, mega and erytroid decrease
trephine biopsy – diffuse infilteration
Immunophenotyping of bone marrow (and/or blood if blast cells present) -- CD 13, 33, 117
Cytochemical analysis – SBBB, MPO, Anae,
Cytogenetic analysis by karyotype
Mutation analysis
Biochemistry (liver, renal, uric acid, calcium, LDH)
Coagulation - PT, PTTK, D dimer, fibringogen
Pregnancy test
Information on oocyte or sperm storage
Assessment of eligibility for stem cell transplantation
Hepatitis B, C and HIV test
CXR with ECG and ECHO in older patients
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