Please enable JavaScript.
Coggle requires JavaScript to display documents.
IMMUNE DISORDERS - Coggle Diagram
IMMUNE DISORDERS
HYPERSENSITIVITIES: any immune response against a foreign antigen that is exaggerated beyond the norm
type II hypersensitivity: cytotoxic: results when cells are destroyed by immune response; due to combined activity of complement and antibodies
hemolytic disease of newborn: Rh- mother & Rh+ fetus; antigens enter mother circulation through breaks in placenta; mother makes anti-Rh antibodies; subsequent pregnancy the antibodies cross the placenta and destroy fetal RBCs
Rhogam: anti-Rh serum administered to Rh- pregnant women; destroys fetal RBCs that enter body; sensitization of the mother does not occur
transfusion reaction: result if individual receives blood of a different blood type; donor blood group may stimulates the production of antibodies that bind and destroy transfused cells
type III hypersensitivity: due to the formation of antigen-antibody complexes; called immune complexes
localized reactions...
glomerulonephritis: immune complexes circulating in the bloodstream are deposited on the walls of glomeruli
hypersensitivity pneumonitis: antigens are inhaled deep into the lungs; stimulates production of antibodies; inhalation of same antigen stimulates immune complexes
-
type I hypersensitivity: immediate; result from the release of inflammatory molecules in response to an antigen; develops with seconds to minutes; commonly called allergies
localized allergic reactions: reactions are mild and localized; site of reaction depends on portal of entry
local dermatitis: produces hives due to release of histamine and the leakage of serum from blood vessels
-
-
systemic allergic reactions: caused by degranulation of many mast cells at once that release large amounts of histamine
-
type IV hypersensitivity: inflammation due to contact with antigens after 12-24 hours; results from interactions of antigen, APCs, and T cells; delay reflects the time it take for macrophages and T cells to migrate and proliferate
-
-
-
tuberculin response: if skin is expose to tuberculosis or vaccine, it reacts to injection beneath the skin
basophils: granules filled with inflammatory chemicals; sensitized basophils bind IgE and degranulate
-
mast cells: found in sites close to body surfaces; granules contain a mixture of potent inflammatory chemicals
-
-