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Clozapine, Teaching Resource - belongs to Dr Emma Ross, Advanced Clinical…

- - - - Weight
      - Obs
      - ECG
  - - - 18wks - weekly
      - 18wks-1yr - fortnightly
      - 1yr+ - 4wkly
      - Green
        
        WBC >3.5
        
        Neuts >2
        
        Give clozapine
      - Amber
        
        WBC 3-3.5
        
        Neuts 1.5-2
        
        Twice wkly FBC until green
      - Red
        
        Neuts <1.5
        
        Stop clozapine
        
        WBC <3
    - - Troponin and CRP
      - ECGs
- - - - Serotonin type 2
      - Norepinephrine
      - Histamine
      - Dopamine type 4
      - Acetylcholine
- - - - 80% respond
- - - - Severe - fatality 20-30%