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Pouchitis Solutions, Brainstorm 1 & 2: Pouchitis Solutions (Divided by…
Pouchitis Solutions
Brainstorm 1 & 2: Pouchitis Solutions (Divided by method)
Artificial Pouches
Prime pouch with gut microbiome during surgery
Solution with ileum completely different from pouch
Artificial (non-ileum) pouch with microbiome
Completely new artificial colon
Colon transplant
Lab-grown pouch to transplant
3D print a pouch
Stem cells to grow a colon
Optimize Current IPAA Surgery
Keep pouch outside the body
Leave some colon behind
Surgically create a different shape of pouch
New method to seal pouch
Quick healing sutures using mesenchymal stem cell coating
Liquid on pouch to prevent bacteria growth
Wound-healing enema after step 1 of 2 step IPAA
AI to optimize IPAA surgery
AI-designed person-specific pouches
Bacteria-Tracking Post-Surgery
Bacteria toilet
C. diff stool treatment
At-home versatile stool test
Insert device into pouch to track bacterial growth
Fluorescent infused shelf on toilet
Pouch bacteria probe alarm
Fart-based diagnostics for C. diff pouchitis
AI guided stool sample analysis
PET probe C. diff visualization
Train dog that senses pouchitis flare
AI sensor in ostomy bag to sense infection in lower stoma
Differentiating UC vs. Crohn's BEFORE Surgery
Fluorescent probe for UC during colonoscopy
Stool test for UC vs. Crohn's biomarkers
Screening pre-surgery
Biopsies from all "unknown colitis" patients to determine biomarker
Pill changes color depending on where inflammation is in GI tract
Burp vs. fart comparison
AI to diagnose UC vs. Crohn's histology
AI wearable to diagnose UC v. Crohn's via vitals
Edible compound that changes color of fecal matter with UC vs. Crohn's cells
Strengthening Microbiome
Strict optimized diet pre- and post-surgery
Engineered fruit with doses of specific healthy microbes
Slowly expose ileum to rectal microbiome before IPAA
Engineer microbiome specifically for ileum
Colonize J-pouch with health bacteria during surgery
Engineer gut microbiome to not cause inflammation
Microbiome mesh during IPAA construction
Machine to run food through to kill/add bacteria
Probiotic mid-hab during ileostomy period
Microbiome filter eliminates harmful bacteria from food passing through
AI suggested diet and lifestyle
Directly kill bacteria pre-infection
Sanitizing underwear
1x day "good liquid" in bottom half of stoma
Flush GI system through ileostomy stoma
Keep pouch cold
Breathing machine that suppresses bacteria
Drink clears all C. diff before surgery
1x day drink that kills harmful bacteria
Antibiotics before surgery
Soup with engineered microbes to kill C. diff
Negative feedback loop antibiotics machine in pouch
Antimicrobial nano-robots that live in pouch and kill bad bacteria
Microbe vacuum
Laser only kills C. diff
Engineered immune system that stays in pouch
Microbubble antibiotics with ultrasound stimulation in pouch
At-home ultrasound stimulation of pouch to kill bacteria
Therapeutic PET radiotracer/therapy that kills C.diff
Antibacterial toothpaste kills bacteria in mouth first
C. diff targeting phages
Mechanical
Rotating scraper that clears bacteria on pouch wall
Metal pouch
"Dialysis method" but for GI system
Squish fecal matter out of pouch 1x day
Automated flushing system with button
Mechanical anal sphincter
Mechanical trap door blocking fecal matter with release button
Prevent pouch leaks
Surgical robot to sterilize during surgery and prevent leaks
Robot senses pouch leak to release sealing substances
Laser fuses pouch leaks
AI sensory in stoma to sense pouch healing
Electrical
Electrical stimulation of pouch smooth muscle to empty fecal matter
Zap all food as it enters the pouch
Engineer voltage-sensitive microbes
Voltage activated macrophages
Brain stimulation to prevent fecal urgency
Brain stimulation to prevent autoimmunity
Optogenetics to control rate of bowel movements
Lab grown pouch with optogenetics and sonic belt with button
"Biomarkers" Predict Pouchitis Flares
Stool classification based on AI images
Large scale data analysis for pouchitis lifestyle factors
App to track symptoms and stool samples
AI track smartwatch metrics to correlate to pouchitis flares
Fluorescent underwear based on fart tests
AI guided fart clustering
Fart @ clinic
Strengthening Pouch
At-home herbal concoction to reduce inflammation
Topical vaccine for pouch against inflammation
Edible-suppository of stem cells to rejuvenate pouch
Two pouches during IPAA surgery automated switch before failure
Pouch with programmed degradation after 5 years
Brainstorm 1: Pouchitis Solutions (Divided by method)
Artificial Pouches
Prime pouch with gut microbiome during surgery
Solution with ileum completely different from pouch
Artificial (non-ileum) pouch with microbiome
Completely new artificial colon
Colon transplant
Lab-grown pouch to transplant
3D print a pouch
Stem cells to grow a colon
Optimize Current IPAA Surgery
Keep pouch outside the body
Leave some colon behind
Surgically create a different shape of pouch
New method to seal pouch
Quick healing sutures
Liquid on pouch to prevent bacteria growth
Wound-healing enema after step 1 of 2 step IPAA
Bacteria-Tracking Post-Surgery
Bacteria toilet
C. diff stool treatment
At-home versatile stool test
Insert device into pouch to track bacterial growth
Fluorescent infused shelf on toilet
Pouch bacteria probe alarm
Fart-based diagnostics for C. diff pouchitis
Differentiating UC vs. Crohn's BEFORE Surgery
Fluorescent probe for UC during colonoscopy
Stool test for UC vs. Crohn's biomarkers
Screening pre-surgery
Biopsies from all "unknown colitis" patients to determine biomarker
Pill changes color depending on where inflammation is in GI tract
Burp vs. fart comparison
Strengthening Microbiome
Strict optimized diet pre- and post-surgery
Engineered fruit with doses of specific healthy microbes
Slowly expose ileum to rectal microbiome before IPAA
Engineer microbiome specifically for ileum
Colonize J-pouch with health bacteria during surgery
Engineer gut microbiome to not cause inflammation
Microbiome mesh during IPAA construction
Machine to run food through to kill/add bacteria
Probiotic mid-hab during ileostomy period
Directly kill bacteria pre-infection
Sanitizing underwear
1x day "good liquid" in bottom half of stoma
Flush GI system through ileostomy stoma
Keep pouch cold
Breathing machine that suppresses bacteria
Drink clears all C. diff before surgery
1x day drink that kills harmful bacteria
Antibiotics before surgery
Soup with engineered microbes to kill C. diff
Negative feedback loop antibiotics machine in pouch
"Biomarkers" Predict Pouchitis Flares
Large scale data analysis for pouchitis lifestyle factors
App to track symptoms and stool samples
Fluorescent underwear based on fart tests
AI guided fart clustering
Fart @ clinic