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HIV/AIDS Drugs - Coggle Diagram
HIV/AIDS Drugs
Transcriptase Inhibitors
Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)
MOA
Drugs
Zidovudine (AZT)
Indications
1st Line NRTI in pregnancy and Pediatrics
Prevents Vertical transmission (Mother to child)
Combinations
AZT + Lamivudine(Combivir)
Adverse
Bone
CNS
Heart
Liver
Lactic Acidosis
General Side-Effects
Fatigue
Myalgia
Anemia
GI
Excretion
Renal
Lamivudine
Side Effects
Well Tolerated
Excretion
Renal
Indications
HIV
Hep B
Emticitabine
Side Effects
Well Tolerated
Excretion
Renal
Didanosine
Side Effects
Pancreatitis
Neuropathy
Lactic Acidosis
Excretion
Renal
Stavudine
Side Effects
Pipodistrophy
Excetion
Renal
Abacavir
Side effect
HSR
Excretion
Liver-ADH
Combination
Abacavir + Lamivudine
Tenofovir
Side Effect
Renal Tox.
Excretion
Renal
Combinations
Tenofovir + Emtricitabine
Tenofovir + Efavirenz
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) ((NEED))
MOA
Non-completely inhibits HIV Reveres Transcriptase/Does not require initial Phosphorylation
Drugs
Delavirdine
Adverse
Rash
Metabolism
CP3A inhibitor
Efavirenz
Adverse
Vivid Dreams
Rash
Dyslipidemia
Metabolism
CYP3A, 2B6 Inducer
Nevirapine
Adverse
Rash
Hepatotoxicity
Metabolism
CYP3A Inducer (Auto-inducer)
Etravirine
Integrase/Protease Inhibitors
Integrase Inhibitors
MOA
Block incorporation of viral DNA into Host DNA for Replication by integrase
Drugs
Raltegravir
Dolutegravir
Elvitegravir
Protease Inhibitors
MOA
Block active site of viral protease
Drugs
Ritonavir
Adverse
GI
Hypertriglyceridemia
Lopinavir
Adverse
GI
Combinations
Lopinavir + Ritonavir
Fosamprenavir + Darunavir
Adverse
Stevens-Johnson Syndrome
Contains Sulfonamide
Fusion/
Entry Inhibitors
Drugs
Maraviroc
MOA
Blocks Chemokine Receptor CCR5 binding C4+ Receptors
Enfuvirtide
MOA
Peptide Entry inhibitor
Prevents GP41 embedding into Host by stopping GP120
Resistance
Mutated GP41
Fostemsavir
Ibalizumab
MOA
Blocks HIV entry into CD4+ T-Cells
Exposure Prophylaxis