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Antiviral Drugs - Coggle Diagram
Antiviral Drugs
CMV/HSV/VZV
HSV
Clovirs (Guanine Analogs)
Adverse:
Crystalline Nephropahty
Resistance
Mutation/deletion of Viral Thymidine Kinase
DNA Polymerase Mutation
Drugs against Resistance
Foscarnet
MOA
Inhibits DNA Pol
Inhibits RNA Pol
Inhibits HIV Reverse Transcriptase
Resistance
Viral Mutation in CMV UL54 Gene (DNA Pol)
Indications
Acyclovir Resistant HSV/VZV
CMV Retinitis Alternative
Adverse
Renal Impairment
3 more items...
Drugs
Acyclovir
MOA
First line
Resistance
Absence of Thymidine Kinase
CMV
EBV
Valacyclovir (prodrug of Acyclovir)
Famciclovir
Penclovir (Metablized from Famciclovir)
Topical
Thymidine Analogs (inhibit DNA Pol)
Idoxuridine
Trifluridine
Indication
Acyclovir-Resistant HSV
Fusion Inhibitor
Docosanol (Abreva)
CMV
(also HSV, VZV, and EBV)
Ganciclovir
Indications
CMV Retinitis (IV)
CMV Prophylaxis (Oral)
CMV Treatment (oral)
MOA
Ganciclovir monophos --> Ganciclovir Triphos by (UL-97)
Ganciclovir Triphosphate Inhibits DNA-Dependent-DNA Pol.
Valganciclovir (Guanosine Analog)
MOA
Prodrug of Ganciclovir
Activated by Phosp. of Viral UL97
Triphosphate inhibits DNA Pol.
Indications
CMV Prophylaxis (transplant)
Hepatitis
HBV (DNA)
Nucleotide Analogues
Ribavirin :red_flag:
MOA :red_flag:
MOA (Guanosine alonog)
Inhibits RNA-dependent DNA polymerase
Inhibits Inosine Monophosphate Dehydrogenase (IMP)
Combination :red_flag:
Ribavirin + INF-a
Indications
Influenza-a + b
Parainfluenza
RSV
Paramyxovirus
HCV
HIV
Adverse :red_flag:
Hemolytic Anemia
Lamivudine :red_flag:
MOA
Inhibits DNA Pol.
Inhibits Reverse Transcriptase (HIV) :red_flag:
Adverse
Rapid Resistance
Adefovir :red_flag:
MOA
Adenine Analog
Inhibits DNA Pol.
Indications
Lamivudine-Resistant HBV :red_flag:
HIV
HSV
Adverse
Toxic
Expensive
Entecavir
MOA
Guanosine Analog
Inhibits HBV pol
100% Bioavailability
Entecavir
Telbivudine
Tenofovir
Interferons :red_flag:
MOA
Upregulate JAK-STAT Upregulate Antiviral Proteins
Adverse
Flu-like symptoms
Depression
Thyroiditis
Combinations
INF-a + Ribavirn
HCV (RNA)
Protease Inhibitors (always Co-administered with Ribavirn) :red_flag:
Sofosbuvir
MOA
Inhibits RNA NS5B Pol.
Combinations
Sofosbuvir + Peginterferon alfa + Ribavirin
Sofosbuvir + Ledipasvir
Adverse
Suicidal Ideation
Contraditions
Pregnancy
Interferons :red_flag:
MOA
Upregulate JAK-STAT Upregulate Antiviral Proteins
Adverse
Flu-Like Symptoms
Depression
Thyroiditis
Combinations
INF-a + Ribavirin
