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Cephalosporins classification - Coggle Diagram
Cephalosporins classification
First gen
Cefazolin
Only parenternal
Cephalexin
Oral
Keflex
Cefadroxil
Oral
Cephradine
Oral & parenternal
Second generation
Cefaclor
Ceclor
Orally active
Cefuroxime
Zinacef
Parenteral
Cefuroxime axcil
Has increased lipophilicity & more orally active
It is a prodrug
Third generation
Cephoperazone
Not orally taken
Most active against pseudomonas
Ceftibuten
Resistance to hydrolysis catalyze by many B- lactamases
Has enhanced chemical stability & orally active
Fourth generation
Enhanced anti staphylococcal activity & broader anti gram negative activity than the third generation
Cefpirome
Newer parenteral
B- Lactamase resistant cephalosporin with quarternary ammonium group at 3-position of Cepheus nucleus
First fourth generation cephalosporin
Cefepime
Parenteral
B-Lactamase resistant
Chem. & microbiologically related to cerfpriome
Broad spectrum
B- Lactamase resistance
Methoximino function in the aminoacyl group
(e.g cefuroxime) the configuration must be syn
–OCH3 at the 7-position of the cephem ring with an α-configuration
Ex: Cephamycins
α-Methoxy group at 7-position give β-lactamase resistance.