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Systemic Lupus Erythematosus (SLE) - Coggle Diagram
Systemic Lupus Erythematosus (SLE)
Pathophysiology
Immune System Dysfunction
Can’t tell self from non-self.
Autoantibodies
B-cells make harmful antibodies
Immune Complexes
Antibodies bind to body tissues.
Inflammation
Immune complexes trigger the complement system
Leads to inflammation and tissue damage.
Organ Damage
Skin
kidneys
heart
lungs
joints
brain
Symptoms
General
Fatigue
fever
weight loss
Musculoskeletal
Joint pain
swelling
arthritis
Dermatologic
Butterfly-shaped rash
sensitivity to sunlight
Renal
Lupus nephritis
proteinuria
reduced kidney function
Cardiovascular
Pericarditis
increased risk of atherosclerosis
heart attack
stroke
Lungs
Pleuritis
Brain
Seizures
mood changes
memory problems
Multi-System Effects
Renal System
kidney failure
Lupus nephritis
immune complexes in glomeruli
Cardiovascular System
Pericarditis
risk of heart attacks and stroke
atherosclerosis
Lungs
Pleuritis
Neurologic System
Seizures
cognitive dysfunction
mood disorders.
Treatment Options
Symptom Management
NSAIDs
corticosteroids
Disease Control
Immunosuppressants
DMARDs
Advanced Therapies
Biologics
belimumab
Organ-Specific Treatments
Stronger drugs prevent kidney failure.
Targeted immunosuppressive therapy
Complications
Cardiovascular Events
Increased risk of heart attack and stroke.
Neuropsychiatric Disorders
Seizures
mood disorders,
cognitive dysfunction.
Renal Failure
chronic kidney disease.
Prognosis
Chronic and Relapsing Nature
flares
remission
Long-Term Management
Symptom control
organ protection
prevention of complications.