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Kirby-Bauer Method - Coggle Diagram

- - - - shallow layer of agar will produce a larger zone of inhibition than a deeper layer.
- - - - Susceptible microorganisms
        
        those that are inhibited by the antimicrobial agent at clinically achievable concentrations
      - Intermediate microorganisms
        
        those that may respond to higher doses of the antimicrobial agent or when concentrations are high at the site of infection.
      - Resistant microorganisms
        
        those that are not inhibited by the antimicrobial agent at clinically achievable concentrations.
- - - - The media or culture is placed in a container and subjected to high-pressure steam at 121°C for 15 minutes.
    - - dry oven at 160-170°C for 2-3 hours
    - - through a membrane filter with a pore size small
- - - - essential in selection of appropriate antibiotic therapy
  - - - food
        
        test antimicrobial activity of preservatives and other food additives
      - cosmetic
        
        efficacy of antimicrobial agent in personal care products
      - pharmaceutical
        
        antimicrobial activity of new drugs and monitor quality of existing drug products
- - - - results can be subjective, leading to potential errors and variablitly in the results
    - - not as sensitive and specific as other anitmicrobial susceptibility testing methods
    - - requires strict qc
    - - variability in growth can affect the size of the zone of inhibition, leading to potential errors