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Genetics and Schizophrenia - Coggle Diagram
Genetics and
Schizophrenia
Hilker
=79% heritability rate
for schizophrenia
DiGeorge Syndrome
=deletion of 30-40 genes
=25% develop schizophrenia
COMT gene
=DiGeorge Syndrome link
=regulates dopamine levels
Family Studies
=whether close bio relatives
also have schizophrenia
=problem of separating effects
of nurture
Gottesman
and Shields
roughly 50% difference in
concordance rate between MZ
ans DZ twins for severe
schizophrenia
57 pairs
schizophrenia has
biological basis
concordance rate isnt
100%
Gottesman 1991
=similar concordance
rates over the years
=could be due to medical
advances and ability
to identify twins
=changing psych
knowledge over time
link
Evaluation
application
=genetic counselling
=likelihood of relatives
developing disorder
very scientific
twin studies have
flawed methodology
=MZ maybe treated
more similarly because
they look the same
reductionist
=genes and NTs
interact with each
other
diathesis stress
model
=biological
predisposition
which is triggered by
environment
=most holistic
over 700 genes
link to schizophrenia
=confusing
no direct
treatments
Individual
Differences
=symptoms are very
diverse
N vs N
=ignores external
influences like
drugs and
deprivation
Dev Psych
=Thomas
=stem from
early brain
abnormalities
=prenatal infection
or poor nutrition