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Cystic Fibrosis - Coggle Diagram
Cystic Fibrosis
Comorbidities
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Constipation (severe, very common)
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Vitamin deficiency (A, D, E, K)
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Increase in risk of colon, breast cancer?
Management
- Early Diagnossi by newborn screen
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- Formalized airway clearnace
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- Pharmacological intervetions
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Diagnostic Criteria
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Lab evidence of abnormal CFTR: Abnormal seat test on 2 occasions or abnormal nasal potential difference
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2 CF disease causing mutations in each copy of CFTR
Investigations
Sweat Test
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Methods
Wescor sweat check
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Management
- Prophylactic Anti-Microbial Therapy
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Respiratory
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Bronchodilate, hydrate, macerate, vibrate, annihilate
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New Treatments
Ivacaftor
Potentiater
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MOA
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Indicated for the management of CF in patients with G551D mutation - Residual CFTR expression with reduced channel conductance
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