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Bone Kinetics - Coggle Diagram
Bone Kinetics
Remodeling Wolff's law: form follows function
Loading
Increased bone mineralization
unloading
Demineralization
Most loads are a combo of tension and compression
Ex: Femoral Neck
Weight bearing
Tension Superiorly
Compression inferiorly
Gluteus Medius forces
Compression superiorly
Tension inferiorly
Strain factors
Magnitude of strain
Minimum effective strain: 0.1% of length
Rate of strain
Distribution of strain
Stimulus for remodelling
Strain factors
Magnitude of strain
Minimum effective strain
Rate of strain
Distribution of strain
Other triggers
environment
age
number of loading cycles
mass needs of skeleton
skeletal damage/microdamage
Low serum calcium level (nutrition)
Bone Anatomy
Structures
Epiphysis
Area at each end of the bone
Osseous in adults
Two types
Traction epiphysis
Pressure epiphysis
Epiphyseal Plate
Cartilaginous area where growth occurs in long bones
Replaced by bone once growth has ended
Diaphysis
Main shaft of bone
center is medullary canal
Metaphysis
the flared part at the end of the diphysis
Endosteum
lines the medullary canal
Periosteum
outermost covering of bone
Types of cells
Osteoprogenitor cells
stem cells derived from mesenchyme
Osteoblasts
produce new bone
Osteocytes
Mature bone cells
Osteoclasts
involved in bone resorption
Chemical Composition of Bone
Organic material
Blood
Cells
Ground Substance (GAGs)
Collagen
Makes up 40% of dry bone tissue (remove water)
Primarily Type I
Inorganic material
Calcium and other Minerals
Hydroxyapatite (HA) Calcium phosphate based
PGs strongly bind to HA due to osteoclacin
Response to Stress
Pressure
Compression of a bone
Traction
Tension on bone
Healing
Fractures
Phases
Inflammation/Hemotoma
Soft callus Formation
Hard (bony) callus formation
Remodeling of callus
Mechanisms
Intramedullary bridging
Functional bracing
allows small degrees of movement
External callus bridging
Casting
Stable Fx
Primary cortical union
Internal fixation
ORIF- screws and plates
Aging
hypermineralization
decreased BMD
Age related apoptosis of chondrocytes
higher Advanced Glycation End Products
EXERCISE can reverse all of these