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BCR signalling, PLCy2 catalyzes the degradation of of the plasma membrane…

- - - - SYK phosphorylates BLNK -> recruitment to ITAMs
        
        BLNK is scaffold protein for
        
        PLCy2
        
        BTK
        
        BTK phosphorylates PLCy2
        
        VAV
        
        GRB2
        
        GRB2 binds and activates SOS
        
        SOS activates the small GTPase RAS
        
        RAF
        
        1 more item...
        
        BLNK and PI3K togetjer activate
      - SYK and LYN together phosphorylate CD19 and BCAP
        
        CD19 and BCAP recruit PI3K to the plasma membrane
        
        BTK
        
        PI3K drives the production of PIP3
- - - - Calmodulin binds to phosphatase calcineurin
        
        Calcineurin dephosphorylates NFAT
        
        NFAT enters nucleus and facilitates cellular activation
  - - - calcium
- - - - Thereby, activation of NF-kB which translocates to ncleus