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Pathology, Disease, Definition - Coggle Diagram

- - - - Morphology
        
        Gross
        
        Swollen, paler, turgid, weightier
        
        Microscopic
        
        Cellular swelling, fatty change
      - Ultrastructural changes
        
        Plasma membrane alterations
        
        Mitochondrial changes
        
        Endoplasmic reticulum changes
        
        Nuclear changes
      - Cells returns to normal upon removal of stimulus
    - - Characteristics
        
        Inability to restore mitochondrial function
        
        Membrane damage
        
        Loss of DNA and chromatin integrity
      - Scenarios
        
        Massive influx of Calcium
        
        Activates degradative enzymes
        
        Injury to lysosomal membrane
  - - - Free radicals
      - bacterial toxins
      - Viral proteins
      - Membrane lysis components of complement system
      - Perforins
      - Various chemicals
      - Radiation
  - - - Progressive degradation action of enzymes on lethally injured cell
      - Morphology
        
        Gross
        
        Solid, grayish, firm well
        
        Liquefied
        
        Microscopic
        
        Cytoplasm
        
        Increased eosinophilia
        
        Nucleus
        
        piknosis
        
        karyorrhesis
        
        Karyolysis
      - Fate of necrotic tissue
        
        Removed by macrophages
        
        healing with scarring
        
        Dystrophic calcification
      - Types
        
        Coagulative
        
        Liquefactive
        
        Gangrenous
        
        Wet
        
        Dry
        
        Caseous
        
        Fat