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Childhood Leukaemia - Coggle Diagram

- - - - Hx / Symptoms
        
        Symptoms of bone marrow failure
        
        Fatigue - low hb
        
        Bruising / petechiae
        
        Bleeding - low platelet
        
        Symptoms of Organ Infiltration
        
        Bone pain. limping
      - Examination / Signs
        
        Signs of Bone marrow failure
        
        Pallor - low hb
        
        Bruising - low platelets
        
        Fever / infection
        
        Signs of Organ Infiltration
        
        Organomegaly
        
        Hepatosplenomegaly
        
        Lymphadenopathy
        
        Mediastinal mass (huge lymph gland)
    - - FBC
        
        Leucocytosis or normal
        
        Neutropenia
        
        Anaemia
        
        Thrombocytopaenia
      - Blood Smear
        
        Blast cells
    - - Morphology
      - Cytochemistry
      - Immunophenotyping
      - CytoGenetics
      - Gene expression profiling
    - - Hyperuricaemia
      - Increased LDH