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IEI - Inborn Errors of Immunity (Primary Immunodeficiencies - PID)1. Birth…

- - - - Severe
      - Persistent
      - Unusual
      - Recurrent
- - - - Allergy
      - Autimmunity (NB Coeliac)
      - Infection NB Resp infx
      - Anaphylaxis to blood products
- - - - Assesses classical pathway
    - - Assesses alternative pathway
    - - Useful in the setting of autoimmune / immune comples disorders
        SLE
        Bacterial endocarditis
  - - - X-linked
      - AR inheritence
    - - Consider familial SLE / early onset autoimmunity
      - Consider invasive meningococcal / pneumococcal disease
    - - Penicillin prophylaxis
      - Additional vaccination against encapsulated organisms
      - Agressive antibiotics for sepsi
      - Medic - aler bracelet