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Rheumatoid Arthritis, image, Osteoclasts, Proteases, image, Bone and…
Rheumatoid Arthritis
Synovial Membrane (Synovium)
Made of FLS (Fybroblasts like Synoviocytes)
Activated
RANKL expression
Stimulates
Secretes
Migrate from joint to joint
Symmetrical Arthritis
Macrophages
Secretes TGF-a, IL-1, IL6
Enhance Inflammation
Stimulates
Stimulates
T-Cells
Inflammation
Secretes IL-17
Macrophage Activity
Stimulate FLS
RANKL
Plasma Cells
Assist in Inflammation
Cytokines and Antibodies
Synovial Fluid
Neutrophils
Proteases
ROS
Immuno Complexes
Vascular Permeability
Adhesion Molecules
Osteoclasts
Bone Erosion
Proteases
Cartilage degradation
Secretes
Epigenetic Modifications, Genetics, Smoking, Inflammations
Modification of autoantigens
APC Activation
Activation of T cells
Activation of B cells
Plasma Cells
Producing auto antibodies
Rheumathoid Factor
Form Immunocomplexes and deposit
Anti-citrullinated protein antibody
Target citrullinated proteins
Bone and Cartilage Degradation
Angiogenesis
Pre-rheumatoid Arthritis
