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Intra epithelial lymphocytes (IEL) - Coggle Diagram
Intra epithelial lymphocytes (IEL)
Induced TCRαβ+CD4+ IEL
Function
Effector memory Th1 and Th17 responses against mucosal pathogens
Influence
Other T cells via its helper function
Dendritic cells
B cells
Via cytokines
IL4
IL10
Activation and promotion of production of IgA
Location
Intestinal mucosa
Also a bit in other mucosal areas
Induced TCRαβ+CD8αβ+ IEL
Function
Effector memory responses
against mucosal pathogens
Pathogenic in celiac disease
Cytotoxic responses against infected or transformed epithelial cells
Location
Intestinal mucosa
Influence
Other T cells
Macrophages
Natural TCR+ IEL
Natural TCRαβ+ IEL
Function
Location
Intestinal mucosa
Influence
Dendritic cells
via cytokines
TGF-β
IL10
dampen the activation of DCs
Macrophages
Via cytokines
IFNγ
IL10
TGF-β
Enhancing pathogen clearance and regulating inflammation.
Other T cells
Shaping the immune response to be pro-inflammatory or regulatory.
B cells
Via cytokines
IL6
TGF-β
Promotion of IgA production (needed in the gut)
Natural TCRγδ+ IEL
Function
Anti-microbial
Promote healing and protect integrity of the intestinal epithelium
protect the intestinal epithelium against attack by pathogenic microorganisms and inflammatory insults
Location
Intestinal mucosa
Influence
Macrophages
Via IFNγ
enhance phagocytic activity and antigen presentation.
Dendritic cells
tailor immune responses towards either pro-inflammatory or regulatory outcomes
Other T cells
promoting regulatory T cells
TCR− IEL
ILC-like IEL
Function
Involved in intestinal inflammatory responses
Location
Intestinal mucosa
Influence
Neutrophils
via IL17
recruits neutrophils to sites of infection
Macrophages
Via cytokines
IFN-γ
TNF-α
Activation of macrophages
Dendritic cells
Other T cells
TCR−iCD3+ IEL
Function
Immune surveillance and stress response
Location
Intestinal mucosa
Influence
Dendritic cells
Via cytokine IFN-γ
Macrophages
NK cells