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Hematopoiesis - Coggle Diagram
Hematopoiesis
Pluripotent hematopoietic stem cell
PU.1
Common lymphoid cell precursor
Common T-cell/ILC precursor
NFIL3, ID2
Common ILC precursor
GATA3, PLZF
IL-7
Common innate lymphocyte precursor
T-bet, NFIL3, RUNX3
IFN gamma
1 more item...
ROR-alpha, BCL11B, GATA3
1 more item...
ROR-gamma-T, TOX, AHR
1 more item...
ROR-gamma-T, AHA, ID2
1 more item...
T-bet, EOMES
IL-15
NK cell
Ex vivo: G-CSF-mobilized CD34+ HSPCs
Addition of SR1 enhances expansion of CD34+ HSPCs and thus induction of expression of NK-cell associated transcription factors promoting NK-cell differentiation
Check markers with flow cytometry, markers CD53-, CD56+
Know simmilarities and differences with Th:
Similar transcription factors & they lookalike
Common T-cell precursor
CD8
Common CD4 T-cell precursor
T-bet, STAT1, 4
IFN-gamma, IL-12
Th1
GATA3, STAT6
IL-4
Th2
FoxP3, STAT5
IL-2, TGF-beta
Treg
ROR-gamma-T
IL-6, 21, 23, TGF-beta
Th17
Bcl-6
IL-6, 21
Tfh
IRF4, PU.1
IL-2, 4, TGF-beta
Th9
Figure in paper: plasticity of Th & ILC
Know the differences between cells and what triggers the switches and what they produce
PAX5, E2A, EBF1
B cell
BLIMP-1
IL-5, 6
Plasma cell
BACH2
Memory B cell
Common myeloid cell precursor
Megakaryocyte-erythroid precursor cell
Erythroblast
Erythrocyte
Megakaryocyte
Platelets
Granulocyte precursor cell
Neutrophil
Eosinophil
Basophil
Monocyte
Macrophage
Dendritic cell
IRF4, 8, ZEB2
pDC
IRF8, ID2, BATF3
cDC1
ID2, NOTCH2, ZEB2, IRF4
cDC2
Know cytokines to create subsets and markers of subsets
Mast cell