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ILC (Innate lymphoid cells) - Coggle Diagram
ILC (Innate lymphoid cells)
ILC1
Origin: CLP (common lymphoid progenitor) --> CILP (common innate lymphoid progenitor) --> CHILP (common helper innate lymphoid progenitor) --> ILCP (innate lymhoid cell precursor)--> ILC1
Location: the dominant ILC subset present in the liver. Their production of IFN–γ promotes the survival of hepatocytes.
Function: Type 1 immunity (macrophage activation, cytotoxicity)
Effector molecules: IFNgamma, Granzymes, Perforin (low levels)
Phenotypical characteristics: CD45, can express CD49a and TRAIL, but often lost upon cell activation and tissue dependent; NKp44, CD127
Functional characteristics:
TF: Tbet
ILC2
Origin
: CLP (common lymphoid progenitor) --> CILP (common innate lymphoid progenitor) --> CHILP (common helper innate lymphoid progenitor) --> ILCP (innate lymhoid cell precursor)--> ILC2
Location
; tissue-resident, imprinted by the tissue of residence ( generally presence of ILC in non-lymphoid tissue is ensured by recruitment of ILC progenitors from blood and maintained by the expression of local survival factors, such as IL-7. ... ILC2 generally
circulates in bloodstream though
Function
: innate counterpart to Th2, responds to large extracellular pathogens and allergens, they regulate adaptive immunity, tissue remodelling/repair and homeostasis of NHSCs / HSCs. Regulation of crosstalk of lymphoid cells with NHSc + spatial organization of immunity
Effector molecules:
IL5 + IL 13 (type 2 cytokines)
Phenotypical characteristics
: CD45+, CD127+, ST2+/-, CD278 (ICOS) ++, IL17-R-beta + , CD294 +
transcriptional characteristics:
specific for ILC2 = GATA3, ROR-alpha
NKcells
Origin: CLP (common lymphoid progenitor) --> CILP (common innate lymphoid progenitor) --> NKP (NK cell precursor) --> NK
Location: NK cells develop in bone marrow as well as in some extramedullar sites, such as lymph nodes, thymus, liver, and uterus.
Function: Type 1 immunity (macrophage activation, cytotoxicity)
mirror the functions of CD8+ cytotoxic T cells
Effector molecules: IFNgamma, Granzymes, Perforin
Phenotypical characteristics: CD45, KLRG1, NKp46, CD122, CD56
Functional characteristics:
TF:Tbet, Eomes
ILC3
Origin
: CLP (common lymphoid progenitor) --> CILP (common innate lymphoid progenitor) --> CHILP (common helper innate lymphoid progenitor) --> ILCP (innate lymhoid cell precursor)--> ILC3
Location
; tissue resident, however often migrates to intestinal lamina propria & draining mesenteric lymph node
Function
counterpart to Th17: combat extracellular microbes (bacteria/funghi)
Effector molecules:
produce IL-17 or IL-22
Phenotypical characteristics
: ILC3 3 subtypes (either LTi, NKp46+ / NKp46-)
transcriptional characteristics:
3 subtypes which all depend of ROR-gammaT transcription factor